If your dose from the concomitant CYP3A4 inducer can't be minimized or discontinued, implant removal might be required plus the affected individual should then be handled using a buprenorphine dosage kind that allows dose adjustments. If a CYP3A4 inducer is discontinued within a individual who is stabilized on buprenorphine, check the affected person for overmedication.
pentobarbital will lower the level or impact of eltrombopag by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.
pentobarbital will lessen the level or influence of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
buprenorphine subdermal implant and pentobarbital equally increase sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom alternate procedure possibilities are inadequate
pentobarbital will reduce the level or influence of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will minimize the level or result of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
fentanyl transdermal and pentobarbital each maximize sedation. Prevent or Use Alternate Drug. Limit use to individuals for whom alternate procedure selections are inadequate
pentobarbital will minimize the level or impact of lefamulin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. more info Keep away from coadministration of lefamulin with solid or moderate CYP3A inducers Except if the gain outweighs threats. Watch for lessened efficacy.
pentobarbital will decrease the level or result of levoketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
pentobarbital will decrease the extent or influence of hydrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will decrease the extent or influence of zolpidem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
pentobarbital will reduce the level or result of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Moderate CYP3A4 inducers might reduce progestin focus; think about use of extra barrier strategies
pentobarbital will decrease the level or outcome of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will decrease the extent or impact of irinotecan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.